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Cascara Sagrada

Introduction

Cascara sagrada is a shrub that grows in North America. The dried bark has been used as a laxative. It can be taken as a pill, liquid, or powder.

Dosages

There are not any advised doses for cascara sagrada.

What Research Shows

May Not Be Effective

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

Cascara sagrada may be safe for most adults to take for a short period of time. Cascara sagrada should not be taken for a long period Cascara sagrada may damage the liver and should not be taken at all by children, during pregnancy or while breastfeeding, or by people with gastrointestinal conditions.B1
Interactions
Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse, such as:
  • Cascara sagrada is a laxative. It may make the medicines you take less effective.
  • Taking cascara sagrada and licorice may lower blood potassium levels.
  • Taking cascara sagrada and other laxatives can cause stomach ulcers.
  • Taking cascara sagrada and opioids or antidopaminergic drugs can cause irregular heart rhythms.
  • People taking blood pressure medication should talk to their doctors before taking cascara sagrada. It can lower blood potassium levels.

References

A
Constipation
A1
Constipation Mueller-Lissner SA, Wald A. Constipation in adults. BMJ Clin Evid. 2010 Jul 5;2010.
B
Safety
B1
Nakasone ES, Tokeshi J. A Serendipitous Find: A Case of Cholangiocarcinoma Identified Incidentally After Acute Liver Injury Due to Cascara sagrada Ingestion. Hawaii J Med Public Health. 2015 Jun;74(6):200-202

Revision Information

  • Reviewer: EBSCO NAT Review Board Eric Hurwitz, DC
  • Review Date: 05/2020
  • Update Date: 06/02/2020