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Indole-3-Carbinol

Supplement Forms/Alternate Names :

  • I3C

Introduction

Indole-3-carbinol is a compound found in broccoli, cabbage, and Brussels sprouts. It can be taken by eating these vegetables or as a pill. Indole-3-carbinol has been used to lower signs of cancer in blood and urine.

Dosages

200 to 400 milligrams once daily

What Research Shows

Not Enough Data to Assess

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

It is likely safe to take indole-3-carbinol in small doses for a short time. C2 Nausea and imbalance may occur with high doses. C1 Not enough studies have been done to say whether it is safe to use for a long period. It is also not known whether it is safe to take by women who are pregnant or breastfeeding.
Interactions
Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.

References

A
Cervical Intraepithelial Neoplasia
A1
Bell MC, Crowley-Nowick P, et al. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol. 2000 Aug;78(2):123-129.
B
Vulvar Intraepithelial Neoplasia
B1
Naik R, Nixon S, et al. A randomized phase II trial of indole-3-carbinol in the treatment of vulvar intraepithelial neoplasia. Int J Gynecol Cancer. 2006 Mar-Apr;16(2):786-790.
C
Safety
C1
Indole-3-carbinol. Monograph. Altern Med Rev. 2005 Dec;10(4):337-342.
C2
Licznerska B, Baer-Dubowska W. Indole-3-Carbinol and Its Role in Chronic Diseases. Adv Exp Med Biol. 2016;928:131-154.

Revision Information

  • Reviewer: EBSCO NAT Review Board Eric Hurwitz, DC
  • Review Date: 02/2020
  • Update Date: 05/27/2020