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Coenzyme Q10

Supplement Forms/Alternate Names:

  • CoQ10
  • Ubiquinone
  • Ubiquinol

Introduction

Coenzyme Q10 is a protein in the body that helps produce energy. It has been used to improve heart function and the health of cells. Coenzyme Q10 can be taken as a pill or powder. It can also be applied to the skin as a cream and has been used to fight signs of aging.

Dosages

100 to 500 milligrams once daily

What Research Shows

Likely Effective

May Be Effective

Unlikely to Be Effective

Not Enough Data to Assess

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

It is likely safe to apply coenzyme Q10 to the skin and to take it orally in small doses for a short time. Not enough studies have been done to say whether it is safe to use for a long period. It is also not known whether it is safe to take by women who are breastfeeding.
Interactions
Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.

References

REFA
Bipolar disorder
REFA1
Mehrpooya M, Yasrebifar F, et al. Evaluating the Effect of Coenzyme Q10 Augmentation on Treatment of Bipolar Depression: A Double-Blind Controlled Clinical Trial. J Clin Psychopharmacol. 2018;38(5):460-466.
REFB
Cardiovascular Disease
REFB1
Flowers N, Hartley L, et al. Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2014;(12):CD010405.
REFC
Coronary Artery Disease
REFC1
Jorat MV, Tabrizi R, et al. The effects of coenzyme Q10 supplementation on lipid profiles among patients with coronary artery disease: a systematic review and meta-analysis of randomized controlled trials. Lipids Health Dis. 2018;17(1):230.
REFD
Diabetes
REFD1
Suksomboon N, Poolsup N, et al. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. 2015;40(4):413-418.
REFD2
Moradi M, Haghighatdoost F, et al. Effect of Coenzyme Q10 Supplementation on Diabetes Biomarkers: a Systematic Review and Meta-analysis of Randomized Controlled Clinical Trials. Arch Iran Med. 2016;19(8):588-596.
REFD3
Stojanović M, Radenković M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutr Res. 2017 Feb;38:1-12.
REFE
Heart Failure
REFE1
Fotino AD, Thompson-Paul AM, et al. Effect of coenzyme Q₁₀ supplementation on heart failure: a meta-analysis. Am J Clin Nutr. 2013 Feb;97(2):268-275.
REFE2
Madmani ME, Yusuf Solaiman A, et al. Coenzyme Q10 for heart failure. Cochrane Database Syst Rev. 2014;(6):CD008684.
REFE3
Lei L, Liu Y. Efficacy of coenzyme Q10 inpatients with cardiac failure: a meta-analysis of clinical trials. BMC Cardiovasc Disord. 2017;17(1):196.
REFE4
Jafari M, Mousavi SM, et al. Coenzyme Q10 in the treatment of heart failure: A systematic review of systematic reviews. Indian Heart J. 2018 Jul;70 Suppl 1:S111-S117.
REFF
Heart Surgery Complications
REFF1
de Frutos F, Gea A, et al. Prophylactic treatment with coenzyme Q10 in patients undergoing cardiac surgery: could an antioxidant reduce complications? A systematic review and meta-analysis. Interact Cardiovasc Thorac Surg. 2015 Feb;20(2):254-259.
REFG
High Blood Pressure
REFG1
Ho MJ, Li EC, et al. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension. Cochrane Database Syst Rev. 2016 Mar 3;3:CD007435.
REFG2
Tabrizi R, Akbari M, et al. The Effects of Coenzyme Q10 Supplementation on Blood Pressures Among Patients with Metabolic Diseases: A Systematic Review and Meta-analysis of Randomized Controlled Trials. High Blood Press Cardiovasc Prev. 2018 Mar;25(1):41-50
REFH
Male Infertility
REFH1
Lafuente R, González-Comadrán M, et al. Coenzyme Q10 and male infertility: a meta-analysis. J Assist Reprod Genet. 2013;30(9):1147-1156.
REFI
Migraine
REFI1
Zeng Z, Li Y, et al. Efficacy of CoQ10 as supplementation for migraine: A meta-analysis. Acta Neurol Scand. 2019 Mar;139(3):284-293.
REFJ
Parkinson Disease
REFJ1
Negida A, Menshawy A, et al. Coenzyme Q10 for Patients with Parkinson’s Disease: A Systematic Review and Meta-Analysis. CNS Neurol Disord Drug Targets. 2016;15(1):45-53.
REFJ2
Zhu ZG, Sun MX, et al. The efficacy and safety of coenzyme Q10 in Parkinson’s disease: a meta-analysis of randomized controlled trials. Neurol Sci. 2017;38(2):215-224.
REFK
Peyronie Disease
REFK1
Safarinejad MR. Safety and efficacy of coenzyme Q10 supplementation in early chronic Peyronie’s disease: a double-blind, placebo-controlled randomized trial. Int J Impot Res. 2010;22(5):298-309.
REFL
Polycystic Ovary Syndrome
REFL1
Samimi M, Zarezade Mehrizi M, et al. The effects of coenzyme Q10 supplementation on glucose metabolism and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Clin Endocrinol (Oxf). 2017;86(4):560-566.
REFM
Statin-Induced Myopathy
REFM1
Banach M, Serban C, et al. Effects of coenzyme Q10 on statin-induced myopathy: a meta-analysis of randomized controlled trials. Mayo Clin Proc. 2015 Jan;90(1):24-34.

Revision Information

  • Reviewer: EBSCO NAT Review Board Eric Hurwitz, DC
  • Review Date: 02/2020
  • Update Date: 06/17/2020