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Dehydroepiandrosterone (DHEA)

Supplement Forms/Alternate Names

  • DHEA, DHEA sulfate

Introduction

Dehydroepiandrosterone (DHEA) is a hormone that the body uses to make sex hormones. It has been used to support fertility treatment and ease the symptoms of irregular hormones. DHEA can be taken as a pill or powder. It can also be injected into the muscle or bloodstream by a health provider.

Dosages

50 to 200 milligrams once daily

What Research Shows

Likely Effective

May Be Effective

Not Enough Data to Assess

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

It is likely safe for most adults to take DHEA in small doses for a short time, but it may cause acne in some people. Taking DHEA orally in high doses may be unsafe. Women who are pregnant or breastfeeding should not take DHEA orally. Not enough studies have been done to say whether it is safe to take for a long period.
Interactions
Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.

References

A
Adrenal Insufficiency
A1
Alkatib AA, Cosma M, et al. A systematic review and meta-analysis of randomized placebo-controlled trials of DHEA treatment effects on quality of life in women with adrenal insufficiency. A Clin Endocrinol Metab. 2009;94(10):3676-3681.
B
Assisted Reproduction Treatment Support
B1
Gleicher N, Barad DH. Dehydroepiandrosterone (DHEA) supplementation in diminished ovarian reserve (DOR). Reprod Biol Endocrinol. 2011 May 17;9:67.
B2
Narkwichean A, Maalouf W, et al. Efficacy of dehydroepiandrosterone to improve ovarian response in women with diminished ovarian reserve: a meta-analysis. Reprod Biol Endocrinol. 2013 May 16;11:44.
B3
Nagels HE, Rishworth JR, et al. Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction. Cochrane Database Syst Rev. 2015;(11):CD009739.
B4
Li J, Yuan H, et al. A meta-analysis of dehydroepiandrosterone supplementation among women with diminished ovarian reserve underdoing in vitro fertilization or intracytoplasmic sperm injection. Int J Gynaecol Obstet. 2015;131(2):240-245.
B5
Zhang M, Niu W, et al. Dehydroepiandrosterone treatment in women with poor ovarian response undergoing IVF or ICSI: a systematic review and meta-analysis. J Assist Reprod Genet. 2016 Aug;33(8):981-991.
B6
Liu Y, Hu L, et al. Efficacy of dehydroepiandrosterone (DHEA) supplementation for in vitro fertilization and embryo transfer cycles: a systematic review and meta-analysis. Gynecol Endocrinol. 2018 Mar;34(3):178-183.
C
Cognitive Function
C1
Grimley Evans J, Malouf R, et al. Dehydroepiandrosterone (DHEA) supplementation for cognitive function in healthy elderly people. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD006221.
D
Depression
D1
Peixoto C, Devicari Cheda JN, et al. The effects of dehydroepiandrosterone (DHEA) in the treatment of depression and depressive symptoms in other psychiatric and medical illnesses: a systematic review. Curr Drug Targets. 2014;15(9):901-914.
E
Menopause
E1
Elraiyah T, Sonbol MB, et al. Clinical review: The benefits and harms of systemic dehydroepiandrosterone (DHEA) in postmenopausal women with normal adrenal function: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2014 Oct;99(10):3536-35342.
E2
Scheffers CS, Armstrong S, et al. Dehydroepiandrosterone for women in the peri- or postmenopausal phase. Cochrane Database Syst Rev. 2015;1:CD011066.
E3
Pitsouni E, Grigoriadis T, et al. Efficacy of vaginal therapies alternative to vaginal estrogens on sexual function and orgasm of menopausal women: A systematic review and meta-analysis of randomized controlled trials. Eur J Obstet Gynecol Reprod Biol. 2018 Oct;229:45-56.
F
Muscle Strength/Physical Function in Older Adults
F1
Baker WL, Karan S, et al. Effect of dehydroepiandrosterone on muscle strength and physical function in older adults: a systematic review. J Am Geriatr Soc. 2011 Jun;59(6):997-1002.
G
Osteoporosis
G1
Whelan AM, Jurgens TM, et al. Natural health products in the prevention and treatment of osteoporosis: systematic review of randomized controlled trials. Ann Pharmacother. 2006 May;40(5):836-849.
H
Sexual Function
H1
Peixoto C, Carrilho CG, et al. The effects of dehydroepiandrosterone on sexual function: a systematic review. Climacteric. 2017 Apr;20(2):129-137.
I
Systemic Lupus Erythematosus
I1
Crosbie D, Black C, et al. Dehydroepiandrosterone for systemic lupus erythematosus. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD005114.

Revision Information

  • Reviewer: EBSCO NAT Review Board Eric Hurwitz, DC
  • Review Date: 02/2020
  • Update Date: 05/27/2020
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