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Superoxide Dismutase

Introduction

Superoxide dismutase is as an antioxidant in the body that helps slow damage to cells. It has been used to promote heart health and prevent signs of aging. Superoxide dismutase has also been used to and ease swelling and pain in the joints and muscles. It can be taken as a pill. It can also be injected into the bloodstream, muscles, and joints by a healthcare provider.

Dosages

There are no advised doses for superoxide dismutase.

What Research Shows

May Be Effective

Not Enough Data to Assess

  • Chronic lung disease in preterm infants B1
  • Chronic neck pain C1
  • Cardiovascular disease in people with chronic kidney disease A1
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

It is likely safe to take superoxide dismutase in small doses for a short time. Not enough studies have been done to say whether it is safe to take for a long period. It is also not known whether it is safe to take by women who are pregnant or breastfeeding.
Interactions
Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.

References

A
Cardiovascular Disease
A1
A1. Jun M, Venkataraman V, et al. Antioxidants for chronic kidney disease. Cochrane Database Syst Rev. 2012;10:CD008176. \
B
Chronic Lung Disease in Preterm Infants
B1
Suresh GK, Davis JM, et al. Superoxide dismutase for preventing chronic lung disease in mechanically ventilated preterm infants. Cochrane Database Syst Rev. 2001;(1):CD001968.
C
Chronic Neck Pain
C1
Letizia Mauro G, Cataldo P, et al. α-Lipoic acid and superoxide dismutase in the management of chronic neck pain: a prospective randomized study. Drugs R D. 2014;14(1):1-7.
D
Stress and Fatigue
D1
Houghton CA, Steels EL, et al. Effects of a gliadin-combined plant superoxide dismutase extract on self-perceived fatigue in women aged 50-65 years. Phytomedicine. 2011 Apr 15;18(6):521-526.
D2
Carillon J, Notin C, et al. Dietary supplementation with a superoxide dismutase-melon concentrate reduces stress, physical and mental fatigue in healthy people: a randomised, double-blind, placebo-controlled trial. Nutrients. 2014 Jun 19;6(6):2348-2359.

Revision Information

  • Reviewer: EBSCO NAT Review Board Eric Hurwitz, DC
  • Review Date: 07/2019
  • Update Date: 03/27/2020
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